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The study: https://pmc.ncbi.nlm.nih.gov/articles/PMC4754566/
First skeptical thoughts: Very low level of evidence.
In this thread, this dude claims that mewing + orthodontic benefits...
https://forum.looksmaxxing.com/thre...sing-vit-c-youre-doing-it-wrong.29548/unread.
There is no proof for mewing, so that's a great start to misinterpreting studies for your own personal gain and cope. https://www.health.com/mewing-7098082
For orthodontic treatment, it does show substantial proof that it works. But let's look at the methodology.
To begin with, the control group did NOT receive any supplemental Vitamin C

This automatically makes it uncomparable or useful to megadose such Vitamin C supplements or dietary Vitamin C.
pmc.ncbi.nlm.nih.gov
Vitamin C deficiency, is extremely rare. So comparing rats who consumed no Vitamin C compared to ones who did, is frankly useless.
pmc.ncbi.nlm.nih.gov
"This study assessed >22,400 participants (aged 40–79 years), revealing a weighted mean of 54 µmol/L vitamin C (48 and 59 µmol/L for men and women, respectively), and a prevalence of deficiency of 1.4% (2.2% for men and 0.8% for women)."
So, if you consume the RDA for Vitamin C, it's unlikely you will require "megadosing" absolutely anything for orthodontic purposes, and isa waste.
While vitamin C is low toxicity, it can cause some issues when receiving over the recommended dose.
www.msdmanuals.com
Significant sources of Vitamin C in food (if you are not receiving sufficient amounts, which COULD lead to slower orthodontic progression)

optimisingnutrition.com
Unlike Vitamin C supplements that only contain Vitamin C, these foods are multi faceted.
@ey88 @Cobicado @N30N @Reciprocated @EndlessRequiem
First skeptical thoughts: Very low level of evidence.
In this thread, this dude claims that mewing + orthodontic benefits...
https://forum.looksmaxxing.com/thre...sing-vit-c-youre-doing-it-wrong.29548/unread.
There is no proof for mewing, so that's a great start to misinterpreting studies for your own personal gain and cope. https://www.health.com/mewing-7098082
For orthodontic treatment, it does show substantial proof that it works. But let's look at the methodology.
To begin with, the control group did NOT receive any supplemental Vitamin C

This automatically makes it uncomparable or useful to megadose such Vitamin C supplements or dietary Vitamin C.
Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern? - PMC
Vitamin C is an essential nutrient that must be obtained through the diet in adequate amounts to prevent hypovitaminosis C, deficiency and its consequences—including the potentially fatal deficiency disease scurvy. Global vitamin C status and ...

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern? - PMC
Vitamin C is an essential nutrient that must be obtained through the diet in adequate amounts to prevent hypovitaminosis C, deficiency and its consequences—including the potentially fatal deficiency disease scurvy. Global vitamin C status and ...

So, if you consume the RDA for Vitamin C, it's unlikely you will require "megadosing" absolutely anything for orthodontic purposes, and isa waste.
While vitamin C is low toxicity, it can cause some issues when receiving over the recommended dose.

Vitamin C Toxicity - Nutritional Disorders - MSD Manual Professional Edition
Vitamin C Toxicity and Nutritional Disorders - Learn about from the MSD Manuals - Medical Professional Version.


Vitamin C Foods: Benefits, Lists, and Recipes
Delve into a comprehensive guide featuring a Vitamin C foods list, benefits of Vitamin C, and recipes to help you harness the power of this vital nutrient.

@ey88 @Cobicado @N30N @Reciprocated @EndlessRequiem